Cellular electrical signals underlie sensation, thought, learning, memory, movement, and hormone secretion. We study life's electrical system from a molecular and biophysical perspective.
The lab focuses on ion channels, transporters, and their regulatory complexes — membrane proteins that form gated pathways for ionic traffic across cell membranes. We aim to understand how these proteins work at a mechanistic level and what roles they play in biology. To do this, we use cryo-electron microscopy, electrophysiology, biophysics, biochemistry, pharmacology, and imaging. Our ultimate goal is to understand the molecular basis of sensory transduction and electrical signaling, and to inform the development of new therapeutic strategies for human disease.
