Electricity is central to life. Sensation of environmental stimuli, thought, learning, memory, and other aspects of neuronal communication, hormone secretion and movement all rely on cellular electrical signals. We study life’s electrical system from a molecular and biophysical perspective.
The focus of the laboratory is on ion channels, transporters and their regulatory complexes that form gated pathways for ionic traffic across cell membranes. We aim to discover how these membrane proteins work at a detailed mechanistic level and what they do in a biological context. To this end, we utilize a range of approaches including structural biology (X-ray crystallography and cryo-EM), electrophysiology, biophysics, biochemistry, pharmacology and imaging. Our goals are to understand the molecular basis of sensory transduction and electrical signaling and to lay the groundwork for development of new approaches to promoting health and treating disease.
Learn more here.
News from the lab:
- 11/2016: Welcome to rotating MCB grad student Nora Kostow!
- 10/2016: Steve receives a NIH Director's New Innovator Award.
- 9/2016: Welcome to 2 rotating graduate students: Chris Hoel from MCB and Francisco Hidalgo from Chemical Biology.
- 8/2016: Steve is awarded a Klingenstein-Simons fellowship award in the Neurosciences.
- 6/2016: Incoming Biophysics student Toby Turney joins the lab for the summer. Welcome Toby!
- 6/2016: Amgen Scholar Joseph Hernandez joins the lab for the summer. Welcome Joseph!
- 5/2016: Robert Rietmeijer joins the lab to pursue his PhD! Welcome aboard Robert :)
- 3/2106: Josefina del Mármol joins the lab as a postdoctoral fellow. Welcome Josefina!
- 2/2016: Our first rotation students start - welcome to Laura Craciun and Justin Zhang from MCB and Robert Rietmeijer from Biophysics!
- 2/2016: Zhu Fu joins the lab as a research specialist. Welcome Zhu!
- 1/2016: ...and we're off! The Brohawn lab is officially open for business :)
- 8/2015: Opening day for the lab is January 1, 2016!