Publications (with links + pdfs) 

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2015

  • How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2. (Review)
    Brohawn, SG. 
    Annals of the New York Academy of Sciences (2015 in press)

2014

  • Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. 
    Brohawn, SG, Campbell, EB & MacKinnon, R. 
    Nature 516, 126-30 (2014) 
    WEB | PDF

    • Press in Rockefeller University Newswire: WEB
    • Comment by Elizabeth Adler in the Journal of General Physiology: WEB
  • Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels.
    Brohawn, SG, Su, Z & MacKinnon, R.
    Proceedings of the National Academy of Sciences 111, 3614–3619 (2014).
     WEB | PDF

2013

  • Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel. 
    Brohawn, SG, Campbell, EB & MacKinnon, R. 
    Proceedings of the National Academy of Sciences 110, 2129–2134 (2013).
    WEB | PDF

2012

  • Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel. 
    Brohawn, SG, del Mármol, J & MacKinnon, R. 
    Science 335, 436–441 (2012).
    WEB | PDF
    • Comment by Hanne Poulsen & Poul Nissen in Science: WEB
    • Comment by Andrew Braun in Channels: WEB
    • Comment by Valda Vinson in Science Signalling: WEB
    • Recommendations by Douglas Bayliss & Jamie Vanderberg in F1000 prime: WEB

2009

  • Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice.
    Brohawn, SG & Schwartz, TU.
    Nature Structure and Molecular Biology 16, 1173–1177 (2009).
    WEB | PDF
  • The nuclear pore complex has entered the atomic age. (Review)
    Brohawn, SG*, Partridge JR*, Whittle, JRR* & Schwartz, TU.
    Structure 17, 1156–1168 (2009).
    WEB | PDF
  • A lattice model of the nuclear pore complex. (Review)
    Brohawn, SG & Schwartz, TU. 
    Communicative and Integrated Biology 2, 205–207 (2009).
    WEB | PDF
  • The structure of the scaffold nucleoporin Nup120 reveals a new and unexpected domain architecture.
    Leksa, NC*, Brohawn, SG* & Schwartz, TU.
    Structure 17, 1082–1091 (2009).
    WEB | PDF
    • Comment by Ingrid Vetter in Structure: WEB

2008

  • Structural evidence for common ancestry of the nuclear pore complex and vesicle coats.
    Brohawn, SG*, Leksa, NC*, Spear, ED, Rajashankar, K & Schwartz, TU.
    Science 322, 1369–1373  (2008).
    WEB | PDF

2006

  • Homodimerization of the G protein SRbeta in the nucleotide-free state involves proline cis/trans isomerization in the switch II region. 
    Schwartz, TU, Schmidt, D, Brohawn, SG & Blobel, G. 
    Proceedings of the National Academy of Sciences 103, 6823–6828 (2006).
    WEB | PDF
    • Recommendation by Martin Pool in F1000 prime: WEB

2004

  • New water-soluble phosphines as reductants of disulfide bonds.
    Cline, DJ, Redding, SE, Brohawn, SG, Psathas, JN, Schneider, JP & Thorpe, C.
    Biochemistry 43, 15195–15203 (2004).
    WEB | PDF
    • Recommendation by Amy Barrios in F1000prime: WEB

2003

  • Avian sulfhydral oxidase is not a metalloenzyme: adventitious binding of divalent metal ions to the enzyme.
    Brohawn, SG, Miksa, IR & Thorpe, C. 
    Biochemistry 42, 11074–11082 (2003).
    WEB | PDF

* designates equal contributions